Concept information
Preferred term
chronic myelogenous leukemia
Definition
- CHRONIC MYELOGENOUS LEUKEMIA (CML) is a malignant clonal disorder of hematopoietic stem cells that results in increases in myeloid cells, erythroid cells, and platelets in the peripheral blood. Philadelphia (Ph) chromosome, formed via translocation t (9; 22), is the cytogenetic hallmark of CML. The translocation forms a chimeric gene, bcr-abl, that generates BCR-ABL, a fusion protein that constitutively activates ABL tyrosine kinase and causes CML. CML has an incidence of 1 to 2 cases per 100,000 people per year and accounts for 15 percent of leukemias in adults. [Source: Encyclopedia of Cancer and Society; Leukemia, Chronic Myelogenous]
Broader concept
Belongs to group
URI
https://concepts.sagepub.com/social-science/concept/chronic_myelogenous_leukemia
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